VITAMIN A
| StockNo |
Product description |
| EB0280-101-15 |
VITAMIN
A VIAL 5 ML OILY SOLUTION 200,000 IU |
-
- COMPOSITION:
Retinol palmitate 200 000 IU in 5 ml oily solution
(1 ml = 40 000 IU).
ACTION:
Vitamin A (axerophtol-retinol) plays an important role in the
processes of biological oxidation - regulates the metabolism of
phospholipides and cholesterol, activates insulin action. It is an
antixerophthalmic, anti-infectious and epithelotonic agent. It
promotes the proper building and development of the epithalial cells
of the skin and mucosae, enhancing the resistance of the epithelial
tissue to physical, chemical and microbial damage. It maintains the
turgor and transparency of cornea cells, facilitates the resynthesis
of rhodopsin and protects against hemeralopia. It ensures the proper
development of the semen in the seminiferous ducts, prevents the
keratinization of the vaginal epithelium and favors the growth of
the young organism. It has an antagonistic action to thyroxine.
Topically applied, it improves the epithelization and granulation of
wounds. After absorption, Vitamin A is hydrolyzed in the liver to
pharmacologically active retinol, which is further glucuronidized or
oxidated to retinal and retinic acid. The usual concentration of
Vitamin A in the blood plasma is between 150 and 280 IU/100 ml. It
is eliminated as metabolites with the urine. The presence of vitamin
A per se has been established in the urine of patients with chronic
nephritis. Vitamin A absorption in the gastrointestinal tract
depends on the functional potential of the pancreas and the release
of bile acids.
INDICATIONS:
Hemeralopia, photophobia, xerophthalmia, follicural keratosis,
keratomalacia; traumas and inflammatory diseases of the eyes; in
dyskeratosis, ichthyosis, diffuse and localized hyperkeratosis,
seborrheic eczema, acne; burns and frosbites of the skin with a
torpid epithelization; catarrh of the respiratory tract, pulmonary
tubeculosis, bronchial asthma; stomatitis, gingivitis, gastritis,
ulcer disease of stomach and duodenum; cholecystitis, cystitis,
pyelitis, etc.; hepatopathy, liver cirrhosis; pregnancy;
hyperthyreosis; retarded growth and maleruption of the teeth in
children; hypovitaminosis A, manifested with enhanced fatigability,
loss of appetite, subacidity, etc.; premenstrual syndrome manifested
with a strong headache, tenseness of the breasts, restlessness. |
SIDE EFFECTS:
In overdosage - hypermia, skin desquamation in the region of the
face and some other places, headache, weakness, loss of appetite,
loss of body weight, slight temperature elevation, tachycardia,
proneness to hemorrhages in the conjuctiva and oral mucosa,
sometimes considerable liver enlargement. These hypervitaminosis
phenomena abate after the drug is withdrawn. Teratogenic effects are
possible when high doses are administered to pregnant women.
DRUG INTERACTIONS:
Both alcohol and retinoides enhance the toxicity of Vitamin A. Oral
contraceptives elevate the level of Vitamin A.
DOSAGE AND ADMINISTRATION:
In lighter cases of deficiency, orally: 15 000 IU (= 0.0045 g)
Vitamin A daily, and in acute deficiency of Vitamin A - orally and
intramuscularly - higher doses, sometimes up to 50 000 IU (= 0.015
g) daily; in hyperthyreosis and skin diseases - 100 000-200 000 IU
(= 0.03-0.06 g) daily for 6 weeks, when the dose is reduced to 50
000 units daily. In strongly manifested premenstrual syndrome, oral
intake of Vitamin A in a dose of 150 000-200 000 IU is
prophylactically recommended ten days before the menstruation is
due.
In newborn babies and infants the dose should not exceed 1000-1500
IU per kg body weight daily.
The maximum doses for adults are 5000 IU per kg body weight daily.
MEDICINAL FORM AND PACKAGE:
Vials of 5 ml with only oily solution of 200 000 IU.
STORAGE:
At moderate temperature (15-30° C), in a place protected from
light.
EXPIRY:
1 (one) year.
|
