MELLIVENON
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| StockNo |
Product description |
Status |
| EB0280-401-01 |
MELLIVENON
OINTMENT 18 G |
 |
| EB0280-401-05 |
MELLIVENON
LINIMENT W CAMPHOR 100 G |
|
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- COMPOSITION:
Standardized bee venom 960 IU, Benzyl ester of nicotinic acid
0.1 g, Camphor 3 g, Chloroform 25 g in liniment.
Standardized bee venom 700 IU, Vitamin H 0.99 g, Benzyl ester of
nicotinic acid 0.36g, Nonylvanylamide 0.072 g, Lavender oil
0.126 g in ointment.
ACTION:
Bee venom is a complex of biologically active substances, some of
them with verified therapeutic effect, e.g. enzymes, hyaluronidase
and phospholipase A, peptides melitin and apamin, hiostamine,
choline, etc. the action of the enzymes is particularly favourable
for inflammatory processes in and around the joints. Its effect on
the pituitary gland-adrenals system is particularly significant for
its therapeutic action, the consequence being corticoid hormone
release. Mellivenon treatment has certain advantages over the
administration of cortisone agents, as the physiological systems of
the organism are activated, not leading to the undesired adverse
effect following long-term administration of cortisone agents. The
enzymes hyaluronidase and phospholipase A have a favourable effect
on the inflammatory processes in joints, nerves, vascular walls,
etc., reducing the reaction of connective tissue and their
anticoagulant action. Bee venom reversibly blocks the sympathetic
ganglia, which explains its vasodilatory action in diseases of the
peripheral arteries. Benzyl ester of nicotinic acid enhances the
vasodilatory action. The revulsive action of mellivenon liniment is
intensified by camphor, which is followed by a light analgesia.
Chloroform, topically applied in higher concentration, blocks the
peripheral sensory receptors which explains its local pain-relieving
action.
INDICATIONS:
Reduction of pain and inflammatory processes in joints and muscles:
in rheumatology - various inflammatory and degenerative articular
and periarticular diseases; in neurology - myositis, neuritis,
neuralgia, lumbago, sciatica, radiculitis, etc.; vascular diseases -
endarteritis, atherosclerosis of limbs, thrombophlebitis,
acrocyanosis, Raynard's disease and other disturbances in peripheral
circulation; non-purulent inflammatory infiltrations, muscle
stiffness after sports, sequelae of sprain, dislocation, contusion,
sport, occupational, etc. traumas, rehabilitation procedures. |
CONTRAINDICATIONS:
Acute infectious diseases, purulent processes, acute stages of
inflammatory articular diseases, enhanced susceptibility
(idiosyncrasy) to bee venom, cachexia, pregnancy. Do not administer
to children below the age of 5.
SIDE EFFECTS:
The side effects of bee venom are due to its histamine-like action.
Bee secretion is of two types: acid - caused very likely by the
local reaction (pain, hyperemia, edema, etc.) and alkaline - causing
convulsions. The general reaction of the venom can be manifested in
indisposition, shivers, headache, nausea, vomiting, elevated body
temperature, and in enhanced susceptibility - urticaria,
palpitation, accelerated pulse, articular pain, convulsions, etc.
DOSAGE AND ADMINISTRATION:
Hypersensitivity test should be performed prior to the initiation of
the treatment - 2-3 liniment drops or 2-3 mm ointment squeezed out
of the tube are rubbed upon 2-3 cubic cm on the skin of the forearm.
In the absence of reddening, itching and swelling at the site of the
application till the 24th h the treatment continues with the rubbing
of small amounts of the agent upon the affected area daily in the
morning and evening. The amounts of the agent rubbed is gradually
increased depending both on the character of the disease and on skin
tolerance till attaining the optimal therapeutic dose which does not
usually exceed 1/3 of the content of the vial or tube. To enhance
the revulsive effect, woolen cloth or flannelette is put upon the
rubbed area. That piece of cloth is not washed or changed till the
end of the treatment. The agent should be lightly rubbed without
massage in case of thrombophlebitis. The duration of the treatment
is from 2 to 8 weeks. After the agent has been rubbed into the skin,
hyperemia can occur at the site of the application for several
hours.
MEDICINAL FORM AND PACKAGE:
Liniment with camphor in vials of 100 g.
Ointment in tubes of 18 g.
STORAGE:
In a cool place (5-15° C) in tightly closed vials and tubes.
EXPIRY:
2 (two) years.
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