ARTHROCHIN

StockNo	Product description	Status
EB0280-408-04	ARTHROCHIN AMPOULE 2 ML (5%)
EB0280-408-18	ARTHROCHIN AMPOULE 5 ML (6.45%)
EB0280-408-19	ARTHROCHIN FILMTABL X 100

 

COMPOSITION:
Chloroquin diphosphate 50 mg/l ml (= 31 mg Chloroquin base); 64.5 mg/l ml (= 40 mg Chloroquine base) in ampoules of 2 ml and 5 ml and 250 mg in one tablet.

ACTION:
A synthetic drug, quickly absorbed in the digestive tract and is partially bound to serum proteins. Its action is associated with the effect on the cellular membranes, as well as with the effect on cell proliferation. It destroys the erythrocytic forms of the malarial plasmodium, some protoza, amebae, the causative agents of fascioliasis. It is still not certain which of its numerous actions is responsible for the effect of arthrochin in rheumatic diseases.
It is fixed in the tissues, mainly in the reticuleondothelial system: liver, spleen muscles, eye, etc.; it is selectively accumulated in considerably higher concentrations in the inflamed tissues. It is metabolized in the liver and is very slowly excreted.

INDICATIONS:
Malaria (therapeutically and prophylactically), amebic hepatitis, abscess in the liver, lambliasis, chronic articular rheumatism, chronic rhematoid arthritis, spondyliis, lupus erythematosus, acne rosacea, lichen ruber planus, trematode invasion, etc.

CONTRAINDICATIONS:
Diffuse hepatic and renal diseases, severe cardiac diseases with rhytmic disorders, diseases of the central nervous system, leukopenia, susceptibility to spasms of the stomach and intestines.

SIDE EFFECTS:
Eye lesions are most frequent: retinopathy manifested with blurred vision, disturbances in color vision; reversible depositions in the cornea. Gastric disturbances (nausea, vomiting, anorexia) have also been observed, as well as rarely - nervous manifestations (dizziness, tinnitus, insomnia, headache). Hepatic injuries are possible, as well as myocardial dystrophy, dermatitis, leukopenia.

DRUG INTERACTIONS:
Its plasma concentration can be increased by simultaneous administration with penicillamine, and its toxic effects can be enhanced.

DOSAGE AND ADMINISTRATION:
Adults - initial dose of 2 tablets daily, taken every 12 h is recommended for the first 2-4 weeks, subsequently transferred to a maintenance dose of 1 tablet daily for months for the treatment of rheumatoid arthritis.
Children - the treatment starts with 1/8 to ½ tablets daily, depending on age.
For malaria treatment, prophylactically - 2 tablets once weekly, and therapeutically for adults - 4 tablets on the first day, at an interval of 6-8 h. On the following days a single tablet is administered.
Special schedules are applied for the other diseases indicated for arthrochin treatment.
Parenterally - up to 10 ml from the solution must be injected deeply intramuscularly and the patient should remain lying for 15-30 min after the injection.

MEDICINAL FORM AND PACKAGE:
Packages with 10 and 50 ampoules of 2 ml and 5 ml (5 % and 6.45%).
Packages with 100 filmtablets.

STORAGE:
At moderate temperature (15-30° C) in a place protected from light.

EXPIRY:
Ampoules - 3 (three) years.
Filmtablets - 2 (two0 years.