AMIDOPHEN

 

StockNo	Product description
EB0280-421-04	AMIDOPHEN SUPPOSITORIES 100 MG X 5
EB0280-421-17	AMIDOPHEN TABL 100 MG X 20
EB0280-421-18	AMIDOPHEN TABL 300 MG X 10

 

COMPOSITION:

Aminophenazone 100 mg in one suppository and
100 mg; 300 mg in one tablet

ACTION:
Amidophen is a non-narcotic analgesic from the group of pyrazolone derivatives. It has antipyretic, analgesic and antiphlogistic effect. The antipyretic effect is due to the inhibition of the thermoregulatory and vasomotor center. That results in dilation of the peripheral blood vessels and heat release is intensified. It suppresses the formation, release and action of various pyrogenic agents, product of bacterial endotoxins. The analgesic and antiphlogistic effect of amidophen is associated with the inhibition of prostaglandin synthesis. It has a slight hypotensive action, as well as a slight spasmolytic effect on smooth muscles.

INDICATIONS:
An analgesic, antipyretic and antiphlogistic drug. It is administered in case of pain of various origin: neuralgia, radiculitis, neuritis, sciatica, headache, arthrosos; in colds and particularly in those with concomitant febrility; in acute rheumatism, as well as in subacute and chronic forms.

CONTRAINDICATIONS:
Hypersensitivity to pyrazolone preparations, diabetes mellitus (increases glycosuria), in high doses in cardiac and vascular diseases, susceptibility to edemas, oliguria, hypotension, states accompanied by leukopenia.

SIDE EFFECTS:
Skin rashes, rarely labial herpes, angioneurotic edema, perspiration, CNS excitation. In very high doses - cyanosis, collapse, convulsions. As a result of the retention of liquids and sodium, it can cause pulmonary edema. The long-term administration can cause granulocytosis or agranulocytosis, especially in subjects with enhanced sensitivity (cautiously in patients undergoing cytostatic treatment). If adynamia and drowsiness occur, amidophen intake is discontinued, and by the decision of the physician - corticosteroids can be prescribed.
Degradation products of amidophen can stain the urine dark yellow or red. The suppositories can cause diarrhea in little children.

DRUG INTERACTIONS:
When mixed with tannin, salts of heavy metals, nitrites, iodine, it is disintegrated and sedimented. It becomes moist when mixed with chloralhydrate, salicylates, urotropin.
Its analgesic action is potentiated by simultaneous intake of phenacetine, analgin, caffeine, phenobarbital.

DOSAGE AND ADMINISTRATION:
Adults - orally, 0.2-0.3 g per intake, 3-4 times daily, most often as tablets. In acute rheumatic attacks - high doses, up to 2 g daily (5 times - 0.2-0.4 g) for 2 to 3 weeks.
Children - orally, from 4 to 12 months old - 0.025-0.05 g per intake, from 2 to 5 years - 0.05-0.1 g per intake, from 6 to 12 years - 0.1-0.15 g per intake.
Children: rectally, aged from 2 to 5 years - 1 suppository of 100 mg, twice daily; from 6 to 12 years - 1 suppository of 100 mg, two to three times daily.

MEDICINAL FORM AND PACKAGE:
Packages with 5 suppositories of 100 mg.
Packages with 20 tablets of 100 mg.
Packages with 10 tablets of 300 mg.

STORAGE:
Suppositories - at a temperature not higher than 25° C.
Tablets - at moderate temperature (15-30° C).

EXPIRY:
Suppositories - 3 (three) years.
Tablets - 2 (two) years.