BUTAPYRIN
-
| StockNo |
Product description |
Status |
| EB0280-421-07 |
BUTAPYRIN
FILMTABL X 40 |
 |
-
- COMPOSITION:
Amidophenazone - 125 mg
Phenylbutazone - 125 mg in one tablet
ACTION:
The combination of the two pyrazolone drugs potentiates reciprocally
their action, hence butapyrin manifests a stronger antiphlogistic,
antipyretic and pain-relieving action, compared to the action of its
components individually. This allows the decrease of the doses of
the components. Butapyrin is characterized by a longer-lasting
action. It inhibits mycopolysaccharide sulfate biosynthesis, which
impeded the formation of collagen in vitro and in vivi.
It affects some enzyme mechanisms of amino acids and aminoglucoside
metabolism, engaging in competitive relationship with the binding of
pyridoxalphosphate and nicotinamide dinucleotide.
INDICATIONS:
Acute, subacute and chronic arthritis, rheumatoid polyarthritis,
Bechterew's disease, spondylosis, gout, bursitis, tendovaginitis,
lumbargo, rheumacarditis. It is also indicated in inflammation of
the serous tunics: pericarditis, pleuritis, polyserositis. It is
administered in neuralgia, pain, sciatia, paresis of the facial
nerve, polyneuritis, chorea minor. It has been used with uncertain
success in the treatment of inflammatory diseases of female
genitalia, herpes zoster, erythema nodosum, pain after traumatic
injuries and operations.
CONTRAINDICATIONS:
Disorders of hepatic and renal functions; cardiac insufficiency;
ulcer disease of the stomach and duodenum; septic states,
tonsillitis, abdominal typhus, paroxysmal epileptic seizures and
tetany. To be cautiously prescribed to elderly and emaciated
patients. |
SIDE EFFECTS:
Those of butadion mainly: irritation of the gastrointestinal tract;
allergic manifestations; retention of water and sodium, damage of
leuykocytes to agranulocyopenia, anemia; sometimes dizziness,
tachycardia and other vegetative symptoms; hyperglycemia, glucosuria.
PRECAUTIONS:
Sodium chloride intake should be restricted so as to reduce edemas.
Weekly checking of peripheral blood count is necessary in order to
detect a negative effect on hematopoiesis, and in case of deviations
the treatment should be discontinued.
DOSAGE AND ADMINISTRATION:
Orally - 1 dragee, 3-4 times daily after meals with a little water,
not chewed. Treatment for one week should be followed by a break of
2-3 days.
Children over 5 years are given a dose of 10 mg/kg body weight daily
at the beginning and later 5 mg/kg body weight. The drug should not
be prescribed to little children and infants.
MEDICINAL FORM AND PACKAGE:
Packages of 40 filmtablets.
STORAGE:
At moderate temperature (15-30° C), in a place protected from
humidity.
EXPIRY:
3 (three) years.
|
