CIMETIDIN
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| StockNo |
Product description |
| EB0280-442-03 |
CIMETIDIN
AMPOULE 10 ML |
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- COMPOSITION:
Cimetidin 1 g/10 ml in one ampoule
ACTION:
Antagonist of histamine H2-receptors. It has a marked inhibitory
action on gastric secretion stimulated by: food, histamine, gastrin,
pentagastrin, acetycholine, insulin. The drug inhibits the basal,
nocturnal and 24-h secretion of gastric acid; it inhibits pepsin
secretion to a lesser extent, but has no effect on the serum level
of gastrin. This mechanism of action leads to marked calming of the
symptoms and improvement in the condition of the patients, when the
disease progresses with hyperacidity, normacidity, and particularly
with duodenal ulcer. In the majority of the patients the therapeutic
effect is manifested as tissue regeneration of the ulcer defect
(gastroscopically verified). The therapeutic effect occurs much
later, subjective complaints are influenced after 10-15 days.
INDICATIONS:
Treatment of duodenal ulcer; treatment and prophylaxis of
gastrointestinal hemorrhages; maintenance treatment and prophylaxis
of recurences, particularly in patients with complicated ulcer
disease (often hemorrhages, perforation). Treatment of Zollinger
Ellison syndrome.
CONTRAINDICATIONS:
Pregnancy and lactation; impaired renal function.
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SIDE EFFECTS:
Diarrhea, rashes, nausea, headache, dizziness are observed only in
single cases, as well as fatigability, insomnia, muscular pains,
changes in the visus. Transitory elevation of transaminase, serum
creatinine and reversible gynecomastia are possible during long-term
treatment.
DRUG INTERACTIONS:
Cimetidin interacts with a large number of pharmaceuticals. It
elevates the level of alcohol, alprazolam, acetylsalicylic acid,
carbamazepine, quinidine, clonazepam, cyancobalamine, diazepam,
digoxin, imipramine, etc. in the blood. It enhances the effects of
tetracyclins. Smoking during treatment reduces its effect.
PRECAUTIONS:
Blood indices should regularly be checked during long-term
treatment. In cases of impaired renal function, the treatment with
cimetidin should be carried out with reduced doses. Do not
administer in parallel with phenytoin.
DOSAGE AND ADMINISTRATION:
Intravenously, particularly in gastrointestinal hemorrhages - it is
administered in a dose of 0.2-0.4 every 6 h during the hemorrhage
period and several hours after the hemorrhage stops.
MEDICINAL FORM AND PACKAGE:
Packages with 10 and 50 ampoules of 10 ml.
STORAGE:
At moderate temperature (15-30° C), in a place protected from
direct sunlight.
EXPIRY:
3 (three) years.
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