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PAPAVERINE HYDROCHLORIDE
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Product description |
| EB0280-444-07 |
PAPAVERINE
HYDROCHLORICUM AMPOULE 1 ML (2%) |
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- COMPOSITION:
Papaverine hydrochloricum 2 %, solution in ampoules of 1 ml
ACTION:
Papaverine is an opium alkaloid; it can also be obtained by
synthesis. It possesses a myotropic spasmolytic action: decreases
the tone and reduces the constrictive activity of the smooth
muscles, mainly the arterioles (coronary, cerebral, pulmonary),
widening them. The smooth muscles of the abdomen are less
susceptible to its action, but in spasms the effect is pronounced.
Papaverine slows down the nerve impulses along the bundle of the
heart, its effect on the latter being similar to that of quinidine.
The mechanism of action of papaverine is not yet fully elucidated;
so far it is clear that it inhibits the enzyme phosphodiesterase and
induces intracellular accumulation of cyclic AMP and binding of the
calcium ions in the tendoplasmic reticulum.
INDICATIONS:
Papaverinum hydrochloricum is indicated for treatment of spasms of
the blood vessels due to hypertension, angina, endarteritis,
cerebral angiospasm of the smooth muscles of the organs in the
abdominal cavity. It alleviates the bronchospasm caused by bronchial
asthma. |
SIDE EFFECTS:
Large doses can cause drowsiness and increased reflectory
excitability. Long-term treatment with papaverine may result in
constipation and other gastric disorders. (if taken orally).
DRUG INTERACTIONS:
Papaverine is synergic with some other spasmolytiocs and
vasodilators.
DOSAGE AND ADMINISTRATION:
Papaverinum hydrochloricum can be applied orally (as powder or
solution), in the rectum, or by injection (subcutaneously,
intramuscularly and intravenously). Subcutaneously: 0.04-0.06 g, up
to several times daily. Intravenously: inject cautiously (danger of
atrioventicular block, extrasystoles, rarely fibrillation) 0.01-0.04
g. it is better to be combined with other spasmolytics. Children
over 6 months: 0.0003-0.02 g per dose, depending on the age.
MEDICINAL FORM AND PACKAGE:
Ampoules containing 1 ml of 2 % solution, in packs of 10 and 50.
STORAGE:
At moderate temperature (15-30° C).
EXPIRY:
2 (two) years.
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